Laboratory of Marc S. Arkovitz, MD
Principal Investigator
Marc S Arkovitz, MD (Assistant Professor of Pediatric Surgery)
Background for Research focus:
Congenital Diaphragmatic Hernia (CDH) is one of the most common congenital disorders occurring in approximately 1 in every 2000 live births. The etiology of the diaphragmatic defects is still unknown. The genetics that control normal and abnormal diaphragmatic development are unknown as is the specific developmental biology of the diaphragm
Main Focus of the Laboratory:
Our lab is currently focusing on the possible role of angiogenesis as it relates to diaphragmatic development. Specifically we are looking at the expression of certain genes important in angiogenesis in the early mouse embryo.
Current Projects:
Sonic Hedgehog in the developing mouse diaphragm
Angiogenesis in the developing mouse diaphragm
Recent Publications:
Cowles RA, Rowe DH and Arkovitz MS. Hereditary Multiple Exostoses of the Ribs: An Unusual Cause of Hemothorax and Pericardial Effusion. Journal of Pediatric Surgery. in press.
Holt PD, Arkovitz MS, Berdon WE and Stolar CJ. Newborns with diaphragmatic hernia: initial chest radiography does not have a role in predicting clinical outcome. Pediatric Radiology. In press.
Arkovitz MS, Hyatt BA and Shannon JM. Lung Development is not necessary for diaphragm development in Mice. Journal of Pediatric Surgery. In press.
Recent (last 5 years) Surgery Residents (Columbia and outside):
My lab was started approximately 1 year ago.
Robert Cowles., the pediatric surgery fellow is the only resident I’ve worked with so far.
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