WHAT'S NEW
Chronic inflammation is a major causative factor in a wide range of diseases, including atherosclerosis (hardening of the arteries), vascular complications of diabetes, macular degeneration, Alzheimer's disease, and autoimmune diseases such as multiple sclerosis and type 1 diabetes.
Even the development of tumors is facilitated by chronic inflammation. During inflammation, a complex series of events occurs in the body's cells.
If one could look into the cells, one would see that certain components become highly activated when the process of inflammation is underway.
One such component, RAGE (receptor for advanced glycation end-products), has been the subject of long and thorough study because of its important contributions to many of the inflammatory conditions considered above.
Since 1990, Ann Marie Schmidt, MD, Director, Division of Surgical Science, has made significant strides in identifying the molecule's functions in the body.
The Division of Surgical Science in the Department of Surgery of the Columbia University College of Physicians and Surgeons, which has been studying the biological pathways of degeneration in the human body for nearly 15 years, has recently received more than $8M from the National Institute on Aging (NIA) to study age-related cardiovascular disease.
Dr. Yan's Research Awarded $7.9M NIA Grant
Shi Du Yan, MD, MS |
Shi Du Yan, MD, MS has received $7.9M competitive renewal grant award from the National Institute on Aging to be used over a five-year period beginning on July 1, 2006.
The grant supports her research on aging and Alzheimer's disease in the Division of Surgical Science.
Dr. Schmidt Is awarded $1.25 Million JDRF Scholar Grant
Ann Marie Schmidt, MD, has been awarded a $1.25 million JDRF Scholar Grant from the Juvenile Diabetes Research Foundation in support of her research protocol "Vascular Injury in Type 1 Diabetes—A Failure of Repair: Probing the Liga."
Translational research is all the rage at Columbia University Medical Center. Not all the rage, perhaps, but work by the Division of Surgical Science on the Receptor for Advanced Glycation Endproducts (RAGE) represents a vitally important segment of translational research currently underway at this institution.
Investigator Grant News
Collaborative Grants
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