Grants
Dr. Shi Du Yan has been awarded a grant on mechanisms of cell stress and survival in neurodegenerative disorders
The National Institutes of Aging has awarded a program project grant on mechanisms of cell stress and survival in neurodegenerative disorders (especially Alzheimer's disease) to Dr. Shi Du Yan, Division of Surgical Science, and her collaborators in the Departments of Surgery, Pathology, Obstetrics & Gynecology, and Medicine. This grant analyzes the role of two molecular targets of amyloid-beta peptide, believed to be the key agent which causes neuronal dysfunction in Alzheimer's disease, in genetically manipulated mice. Drs. Mayeux and Shelanski from the Taub Center are collaborators in this work.
Dr. Evanthia Lalla receives grant to conduct research on atherosclerosis and oral infection (School of Dental and Oral Surgery)
The National Institutes of Health has awarded a research grant on atherosclerosis and oral infection to Dr. Evanthia Lalla, School of Dental and Oral Surgery, and her collaborator, Dr. Ann Marie Schmidt, Division of Surgical Science.
This grant explores the multifactoral mechanisms underlying accelerated atherosclerosis in periodontitis.
It will analyze the factors accelerating vascular inflammation and atherosclerosis in periodontitis.
Grant awarded to Dr. Regina Landsberg on RAGE and TMJ arthritis (School of Dental and Oral Surgery)
Dr. Regina Landsberg, School of Dental and Oral Surgery, has been awarded a grant from The National Institutes of Health on RAGE and TMJ arthritis.
This is a collaborative grant with Dr. Ann Marie Schmidt.
The grant will test the role of RAGE in joint/bone inflammation and destruction, and will assess the impact of pharmacologic blockade of RAGE, as well as genetic manipulation of the receptor in homozygous RAGE null mice.
If successful, these studies will identify new markers for disease activity in TMD, as well as new targets for therapeutic intervention.
Dr. Vivette D'Agati receives grant to conduct research on RAGE and glomerulosclerosis (Health Sciences, Department of Pathology)
The National Institutes of Health has awarded a research grant on RAGE and glomerulosclerosis to Dr. Vivette D'Agati, Department of Pathology.
Dr. Ann Marie Schmidt is a close collaborator in the research. The study proposes that identification of RAGE-dependent mechanisms that impart injury, especially early after triggering insults, such as administration of adriamycin in a model system, are essential steps to identification of new targets whose blockade may lead to novel therapies to prevent, stabilize or reverse the course of injury in chronic GS.
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