Projects

Preparing to put Liver on Pump

Liver on Pump

Mechanisms of antibody mediated rejection and accommodation. We use genetically modified transplant models of kidney and cardiac transplantation.
Hypothermic Machine Perfusion of Liver Grafts
Simple cold storage (CS) is the only form of liver preservation currently utilized. Machine preservation (MP) using continuous hypothermic perfusion has led to improved results in extended criteria donor kidneys and has been an area of interest in many animal liver transplant models. Machine preservation allows removal of waste products, delivery of metabolic substrates and maintenance of the microvascular integrity of the graft during the preservation period.

Pulsatile Renal Preservation: Long term pulsatile preservation with novel perfusates will be tested in large animal and human discard organ models. A normothermic oxygenated reperfusion model will allow histologic and functional evaluation of kidneys receiving novel perfusates or other protective agents in preservation injury
Xenotransplant/Incompatible model: using ex-vivo perfusion techniques, we have developed a robust "functioning kidney model" of incompatible transplantation and xenotransplantation. Collaborative projects with other departments investigating antibody mediated rejection, complement activation and cellular rejection are being designed using our ex-vivo kidney model.

Ex vivo Renal perfusion