Current Research & Innovations Thoracic

Cystic Fibrosis

In recent years, some important findings have taken place in CF research. Scientists have isolated the gene responsible for cystic fibrosis and have begun developing treatment techniques that will repair the genetic defect in a patient's lung tissue. Researchers have also identified an abnormality in the regulation of a cellular channel through which chloride ions move that may play a role in the disease. Both of these scientific discoveries promise better understanding of cystic fibrosis, better forms of treatment, and possible prevention.

Physicians in the Columbia Presbyterian Cystic Fibrosis Treatment Center regularly participate in clinical research trials studying new treatments for the management of cystic fibrosis. Milestone studies include the Pulmozyme trial, the Thairapy Vest trial, and the TOBI trial.

In addition, Columbia researchers have a long track record of basic science contributions to the field of cystic fibrosis. Several renowned scientists have laboratories dedicated to the further understanding of the disease, with support from the NIH and the Cystic Fibrosis Foundation. Specifically, investigators from Columbia have made major contributions to understanding the electrolyte abnormalities in CF, as well as the mechanisms of lung inflammation associated with the disease.