Profile image of Mercedes  Martinez, MD

Mercedes Martinez, MD

Medical Director, Adult and Pediatric Intestinal/Multivisceral Transplant Program, Center for Liver Disease and Abdominal Organ Transplantation, NYP
Clinical Director, Human Studies Core, Columbia Center for Translation Immunology
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Expertise:

Autoimmune Hepatitis
Autoimmune Liver Disorder
Gastrointestinal Bleeding
Gastrointestinal ERCP
Gastrointestinal Tumors
Hepatic Disorders
Hepatitis
Hepatitis B
Hepatobiliary Pancreas Disease
Hepatology
Intestinal Atresia
Intestinal Transplant
Liver Disease In Children
Liver Transplantation
Liver Tumors
Pediatric Gastroenterology
Pediatric Liver Cancer
Pediatric Liver Disease-Acute
Pediatric Liver Disease-Chronic
Pediatric Transplant Hepatology
Pediatrics
Short Bowel Syndrome

About:

Mercedes Martinez, MD, is a Professor of Pediatrics and Medicine, the Medical Director of the Intestinal Transplant Program at the Center for Liver Disease and Abdominal Organ Transplantation, and the Medical Director, Pediatric Abdominal Organ Transplantation Transplant at NewYork-Presbyterian. She provides state-of-the-art care for children with a multitude of liver and intestinal issues, including children with liver and intestinal failure that require transplantation and for those with intestinal failure associated liver disease. Dr. Martinez is nationally and internationally recognized for her expertise in treating liver tumors and autoimmune liver disorders. Her research interests include liver biomarkers of operational tolerance and personalized immunosuppression, liver tumors in children, autoimmune liver diseases, metabolic disorders, nutritional deficiencies associated with liver diseases, and intestinal failure. In addition, she has been part of multi-center collaborative efforts to study the impact of autoimmune liver disorders in children and clinical trials of immunosuppression withdrawal.

Visit The Center for Liver Disease and Transplantation at columbiasurgery.org/liver

Honors:

2016-2022 New York Magazine Best Doctors

2018 Academy of Clinical Excellence?at Columbia University (ACE)

2015-2016 Faculty Leadership Academy

2019-2022 Exceptioanl Women In Medicine

Interests:

Intestinal Transplant Rejection, Transplant Immunology, Immunotolerance

Publications:

Troendle DM, Ruan W, Fishman DS, Barth BA, Liu QY, Giefer M, Kim KM, Martinez M, Dall'oglio L, Torroni F, De Angelis P, Faraci S, Bitton S, Wilsey M, Khalaf R, Werlin S, Dua K, Gugig R, Huang C, Mamula P, Quiros JA, Zheng Y, Grover A, Fox VL. Technical Outcomes in Pediatric Endoscopic Retrograde Cholangiopancreatography: Data from an International Collaborative. J Pediatr Gastroenterol Nutr. 2022 Sep 19;. doi: 10.1097/MPG.0000000000003612. [Epub ahead of print] PubMed PMID: 36122368.

Bowlus CL, Arrivé L, Bergquist A, Deneau M, Forman L, Ilyas SI, Lunsford KE, Martinez M, Sapisochin G, Shroff R, Tabibian JH, Assis DN. AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma. Hepatology. 2022 Sep 9;. doi: 10.1002/hep.32771. [Epub ahead of print] PubMed PMID: 36083140.

Perito ER, Persyn E, Bucuvalas J, Martinez M, Mohammad S, Squires JE, Demetris AJ, Feng S. Graft Fibrosis Over 10 to 15 Years in Pediatric Liver Transplant Recipients: Multicenter Study of Paired, Longitudinal Surveillance Biopsies. Liver Transpl. 2022 Jun;28(6):1051-1062. doi: 10.1002/lt.26409. Epub 2022 Feb 23. PubMed PMID: 35029022.

Kang E, Martinez M, Moisander-Joyce H, Saenger YM, Griesemer AD, Kato T, Yamashiro DJ, Remotti H, Gartrell RD. Stable liver graft post anti-PD1 therapy as a bridge to transplantation in an adolescent with hepatocellular carcinoma. Pediatr Transplant. 2022 May;26(3):e14209. doi: 10.1111/petr.14209. Epub 2021 Dec 15. PubMed PMID: 34907641; PubMed Central PMCID: PMC9035049.

Griesemer A, Martinez M, Emond JC. Autologous Stem Cell Transplant to Treat Recurrent Primary Sclerosing Cholangitis: Tolerance, But at What Price?. Transplantation. 2022 Mar 1;106(3):458-459. doi: 10.1097/TP.0000000000003830. PubMed PMID: 34033607.

Liu QY, Ruan W, Fishman DS, Barth BA, Tsai CM, Giefer MJ, Kim KM, Martinez M, Dall'Oglio L, De Angelis P, Torroni F, Faraci S, Bitton S, Wilsey M, Khalaf RT, Werlin S, Dua K, Huang C, Gugig R, Mamula P, Fox VL, Grover AS, Quiros JA, Zheng Y, Troendle DM. Predictors of Prolonged Fluoroscopy Exposure in Pediatric Endoscopic Retrograde Cholangiopancreatography: Results From the Large Pediatric Endoscopic Retrograde Cholangiopancreatography Database Initiative Multicenter Cohort. J Pediatr Gastroenterol Nutr. 2022 Mar 1;74(3):408-412. doi: 10.1097/MPG.0000000000003347. PubMed PMID: 34724445.

Grabinski ZG, Boscamp NS, Zuckerman WA, Zviti R, O'Brien A, Martinez M, Tsze DS. Efficacy of Distraction for Reducing Pain and Distress Associated With Venipuncture in the Pediatric Posttransplant Population: A Randomized Controlled Trial. Pediatr Emerg Care. 2022 Feb 1;38(2):e811-e815. doi: 10.1097/PEC.0000000000002458. PubMed PMID: 34034337.

Kehar M, Ebel N, Ng V, Lobritto S, Martinez M. Updates From the NASPGHAN/SPLIT SARS-CoV2 International Registry. J Pediatr Gastroenterol Nutr. 2022 Feb 1;74(2):e43-e44. doi: 10.1097/MPG.0000000000003326. PubMed PMID: 34654794; PubMed Central PMCID: PMC8788628.

Squires JE, Alonso EM, Ibrahim SH, Kasper V, Kehar M, Martinez M, Squires RH. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper on the Diagnosis and Management of Pediatric Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2022 Jan 1;74(1):138-158. doi: 10.1097/MPG.0000000000003268. PubMed PMID: 34347674.

Nicastro E, Ebel NH, Kehar M, Czubkowski P, Ng VL, Michaels MG, Lobritto SJ, Martinez M, Indolfi G. The Impact of Severe Acute Respiratory Syndrome Coronavirus Type 2 on Children With Liver Diseases: A Joint European Society for Pediatric Gastroenterology, Hepatology and Nutrition and Society of Pediatric Liver Transplantation Position Paper. J Pediatr Gastroenterol Nutr. 2022 Jan 1;74(1):159-170. doi: 10.1097/MPG.0000000000003339. PubMed PMID: 34694269; PubMed Central PMCID: PMC8673661.

Kang E, Shin JI, Griesemer AD, Lobritto S, Goldner D, Vittorio JM, Stylianos S, Martinez M. Risk Factors for 30-Day Unplanned Readmission After Hepatectomy: Analysis of 438 Pediatric Patients from the ACS-NSQIP-P Database. J Gastrointest Surg. 2021 Nov;25(11):2851-2858. doi: 10.1007/s11605-021-04995-2. Epub 2021 Apr 6. PubMed PMID: 33825121.

Goldner D, Vittorio J, Barrios DM, McGuire J, Brodlie S, Brown J, Lobritto S, Martinez M. Bone Fractures in Children With Cholestatic Liver Disease May Mimic Those Seen in Child Abuse. Pediatr Emerg Care. 2021 Oct 1;37(10):e636-e639. doi: 10.1097/PEC.0000000000001740. PubMed PMID: 30672906.

Yilmaz MM, Martinez M, Ko HM. Gastrointestinal Manifestations of a Rare Lipid Storage Disorder. Gastroenterology. 2021 Oct;161(4):e5-e6. doi: 10.1053/j.gastro.2021.02.032. Epub 2021 Feb 18. PubMed PMID: 33609508.

Martinez M, Perito ER, Valentino P, Mack CL, Aumar M, Broderick A, Draijer LG, Fagundes EDT, Furuya KN, Gupta N, Horslen S, Jonas MM, Kamath BM, Kerkar N, Kim KM, Kolho KL, Koot BGP, Laborda TJ, Lee CK, Loomes KM, Miloh T, Mogul D, Mohammed S, Ovchinsky N, Rao G, Ricciuto A, Rodrigues Ferreira A, Schwarz KB, Smolka V, Tanaka A, Tessier MEM, Venkat VL, Vitola BE, Woynarowski M, Zerofsky M, Deneau MR. Recurrence of Primary Sclerosing Cholangitis After Liver Transplant in Children: An International Observational Study. Hepatology. 2021 Oct;74(4):2047-2057. doi: 10.1002/hep.31911. Epub 2021 Sep 9. PubMed PMID: 34008252; PubMed Central PMCID: PMC8530456.

Perez A, Cantor A, Rudolph B, Miller J, Kogan-Liberman D, Gao Q, Da Silva B, Margolis KG, Ovchinsky N, Martinez M. Liver involvement in children with SARS-COV-2 infection: Two distinct clinical phenotypes caused by the same virus. Liver Int. 2021 Sep;41(9):2068-2075. doi: 10.1111/liv.14887. Epub 2021 Apr 22. PubMed PMID: 33826804; PubMed Central PMCID: PMC8251417.

Sin P, Díaz LA, Martínez M, Vizcaya C, D'Agostino D, Gana JC. Acute Liver Injury Among Pediatric Liver Transplantation Recipients With Coronavirus Disease 2019: An International Collaborative Study. J Pediatr Gastroenterol Nutr. 2021 Sep 1;73(3):391-394. doi: 10.1097/MPG.0000000000003213. PubMed PMID: 34183614; PubMed Central PMCID: PMC8373390.

Fishman DS, Barth B, Man-Wai Tsai C, Giefer MJ, Martinez M, Wilsey M, Khalaf RT, Liu QY, DeAngelis P, Torroni F, Faraci S, Troendle DM. A prospective multicenter analysis from the Pediatric ERCP Database Initiative: predictors of choledocholithiasis at ERCP in pediatric patients. Gastrointest Endosc. 2021 Aug;94(2):311-317.e1. doi: 10.1016/j.gie.2021.01.030. Epub 2021 Feb 1. PubMed PMID: 33539907.

Kehar M, Ebel NH, Ng VL, Baquero JER, Leung DH, Slowik V, Ovchinsky N, Shah AA, Arnon R, Miloh T, Gupta N, Mohammad S, Kogan-Liberman D, Squires JE, Sanchez MC, Hildreth A, Book L, Chu C, Alrabadi L, Azzam R, Chepuri B, Elisofon S, Falik R, Gallagher L, Kader H, Mogul D, Mujawar Q, Namjoshi SS, Valentino PL, Vitola B, Waheed N, Zheng MH, Lobritto S, Martinez M. Severe Acute Respiratory Syndrome Coronavirus-2 Infection in Children With Liver Transplant and Native Liver Disease: An International Observational Registry Study. J Pediatr Gastroenterol Nutr. 2021 Jun 1;72(6):807-814. doi: 10.1097/MPG.0000000000003077. PubMed PMID: 33605666; PubMed Central PMCID: PMC8183254.

El-Matary W, Guthery SL, Amir AZ, DiGuglielmo M, Draijer LG, Furuya KN, Gupta N, Hochberg JT, Horslen S, Kerkar N, Koot BGP, Laborda TJ, Loomes KM, Mack C, Martinez M, Miethke A, Miloh T, Mogul D, Mohammed S, Moroz S, Ovchinsky N, Perito ER, Rao G, Ricciuto A, Sathya P, Schwarz KB, Shah U, Singh R, Soufi N, Valentino PL, Zizzo A, Deneau MR. Colorectal Dysplasia and Cancer in Pediatric-Onset Ulcerative Colitis Associated With Primary Sclerosing Cholangitis. Clin Gastroenterol Hepatol. 2021 May;19(5):1067-1070.e2. doi: 10.1016/j.cgh.2020.04.055. Epub 2020 Apr 29. PubMed PMID: 32360820; PubMed Central PMCID: PMC8788582.

Feng S, Bucuvalas JC, Mazariegos GV, Magee JC, Sanchez-Fueyo A, Spain KM, Lesniak A, Kanaparthi S, Perito E, Venkat VL, Burrell BE, Alonso EM, Bridges ND, Doo E, Gupta NA, Himes RW, Ikle D, Jackson AM, Lobritto SJ, Jose Lozano J, Martinez M, Ng VL, Rand EB, Sherker AH, Sundaram SS, Turmelle YP, Wood-Trageser M, Demetris AJ. Efficacy and Safety of Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients: Moving Toward Personalized Management. Hepatology. 2021 May;73(5):1985-2004. doi: 10.1002/hep.31520. PubMed PMID: 32786149.

Mohammad S, Sundaram SS, Mason K, Lobritto S, Martinez M, Turmelle YP, Bucuvalas J, Feng S, Alonso EM. Improvements in Disease-Specific Health-Related Quality of Life of Pediatric Liver Transplant Recipients During Immunosuppression Withdrawal. Liver Transpl. 2021 May;27(5):735-746. doi: 10.1002/lt.25963. PubMed PMID: 33280227; PubMed Central PMCID: PMC8185886.

Fu J, Zuber J, Shonts B, Obradovic A, Wang Z, Frangaj K, Meng W, Rosenfeld AM, Waffarn EE, Liou P, Lau SP, Savage TM, Yang S, Rogers K, Danzl NM, Ravella S, Satwani P, Iuga A, Ho SH, Griesemer A, Shen Y, Prak ETL, Martinez M, Kato T, Sykes M. Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation. J Clin Invest. 2021 Apr 15;131(8). doi: 10.1172/JCI141698. PubMed PMID: 33630757; PubMed Central PMCID: PMC8062082.

Miller J, Martinez M, Margolis K. Reply. Gastroenterology. 2021 Apr;160(5):1888-1889. doi: 10.1053/j.gastro.2021.01.016. Epub 2021 Jan 13. PubMed PMID: 33453228; PubMed Central PMCID: PMC7836913.

Deneau MR, Mack C, Perito ER, Ricciuto A, Valentino PL, Amin M, Amir AZ, Aumar M, Auth M, Broderick A, DiGuglielmo M, Draijer LG, Tavares Fagundes ED, El-Matary W, Ferrari F, Furuya KN, Gupta N, Hochberg JT, Homan M, Horslen S, Iorio R, Jensen MK, Jonas MM, Kamath BM, Kerkar N, Kim KM, Kolho KL, Koot BGP, Laborda TJ, Lee CK, Loomes KM, Martinez M, Miethke A, Miloh T, Mogul D, Mohammad S, Mohan P, Moroz S, Ovchinsky N, Palle S, Papadopoulou A, Rao G, Rodrigues Ferreira A, Sathya P, Schwarz KB, Shah U, Shteyer E, Singh R, Smolka V, Soufi N, Tanaka A, Varier R, Vitola B, Woynarowski M, Zerofsky M, Zizzo A, Guthery SL. The Sclerosing Cholangitis Outcomes in Pediatrics (SCOPE) Index: A Prognostic Tool for Children. Hepatology. 2021 Mar;73(3):1074-1087. doi: 10.1002/hep.31393. Epub 2020 Dec 19. PubMed PMID: 32464706; PubMed Central PMCID: PMC8557635.

Deneau MR, Mack C, Mogul D, Perito ER, Valentino PL, Amir AZ, DiGuglielmo M, Draijer LG, El-Matary W, Furuya KN, Gupta N, Hochberg JT, Horslen S, Jensen MK, Jonas MM, Kerkar N, Koot BGP, Laborda TJ, Lee CK, Loomes KM, Martinez M, Miethke A, Miloh T, Mohammad S, Ovchinsky N, Rao G, Ricciuto A, Sathya P, Schwarz KB, Shah U, Singh R, Vitola B, Zizzo A, Guthery SL. Oral Vancomycin, Ursodeoxycholic Acid, or No Therapy for Pediatric Primary Sclerosing Cholangitis: A Matched Analysis. Hepatology. 2021 Mar;73(3):1061-1073. doi: 10.1002/hep.31560. PubMed PMID: 32946600; PubMed Central PMCID: PMC8557636.

Deneau M, Mack C, Valentino PL, Amir AZ, DiGuglielmo M, Draijer LG, El-Matary W, Furuya KN, Gupta N, Hochberg JT, Horslen S, Jensen MK, Jonas M, Kerkar N, Koot B, Laborda TJ, Lee, CK, Loomes KM, Martinez M, Miethke A, Miloh T, Mogul D, Mohammed S, Ovchinsky N, Perito E, Rao G, Ricciuto A, Sathya P, Schwarz KB, Shah U, Singh R, Smolk, Vitola B, Zizzo A, Guthery S. Oral vancomycin, Ursodeoxycholic acid or no therapy for pediatric primary sclerosing cholangitis: a matched analysis. Hepatology. 2020 Sep 18. doi: 10.1002/hep.31560. Online ahead of print. PMID:?32946600

Fu J, Zuber J, Shonts B, Obradovic A, Frangaj K, Meng W, Rosenfeld A, Waffarn EE, Liou P, Wang Z, Lau SP, Savage TM, Yang S, RogersK, Danzl NM, Ravella S, Satwani P, Iuga A, Ho SH, Griesemer A, Farber DL, Shen Y, Luning Prak ET, Martinez M, Kato T, Sykes M. Promotion of Mixed Chimerism by Lymphohematopoietic Graft-versus-Host Responses in Patients Receiving Intestinal Transplantation. Accepted Journal of Clinical Immunology

Feng S, Bucuvalas J, Spain KM, Lesniak A, Kanaparthi S, Sanchez-Fueyo A, Magee JC, Perito E, Burrell BE, Venkat V, Mazariegos GV, Alonso EM, Bridges NE, Doo E, Gupta NA, Himes RW, Ikle D, Jackson AM, Lobritto SJ, Martinez M, Ng VL, Rand EB, Sherker AH, Sundaram S, Turmelle YP, Wood-Trageser M, and Demetris AJ. Efficacy and Safety of Immunosuppression Withdrawal for Long-term Pediatric Liver Transplant Recipients: Moving Towards Personalized Management. Hepatology. 2020 Aug 12. doi: 10.1002/hep.31520. PMID:?32786149

Trevor J. Laborda JT, Ricciuto A, Aumar M, Carman N, DiGuglielmo M, Draijer LG, Furuja KN, Gupta N, Koot BGP, Loomes. KM, Lytvyak E, Martinez M, Miloh T, Montano-Loza A, Periro ER, Sathya, Shah U, Shteyer E, Singh R, Taylor A, Valentino PL, Vitola B, Zerofsky M, Zizzo A, Denau MR. Vedolizumab therapy for children with primary sclerosing cholangitis: data from the pediatric PSC consortium. J. Pediatr Gastroenterol Nutr.?2020 Jul 28.doi: 10.1097/MPG.0000000000002855. PMID:?32740528

Miller J, Cantor A, Zachariah P, Ahn D, Martinez M, Margolis K. Gastrointestinal symptoms as a major presentation component of a novel multisystem inflammatory syndrome in children (MIS-C) that is related to COVID-19: discussion of a one center experience of 44 cases. Gastroenterology. 2020 Jun 4;S0016-5085(20)34753-3. doi: 10.1053/j.gastro.2020.05.079. PMID:?32505742 PMCID:?PMC7270806

Deneau M, Mack C, Valentino PL, Abdou R, Alqoaer K, Amin M, Amir AZ, Aumar M, Auth M, Broderick A, DiGuglielmo M, Draijer LG, Tavares Fagundes ED, El-Matary W, Ferrari F, Furuya KN, Gupta N, Homan M, Horslen S, Iorio R, Jensen MK, Jonas M, Kamath BM, Kerkar N, Kim KM, Kolho KL, Koot B, Laborda TJ, Lee, CK, Loomes KM, Martinez M, Miethke A, Miloh T, Mogul D, Mohammed S, Mohan P, Ovchinsky N, Palle S, Papadopoulou A, Perito E, Rao G, Ricciuto A, Rofrigues Ferreira A, Sathya P, Schwarz KB, Shah U, Shteyer E, Singh R, Smolka V, Tanaka A, Varier R, Vitola B, Woynarowski M, Zerofsky M, Zizzo A, Guthery S. Sclerosing Cholangitis Outcomes in Pediatrics (SCOPE) index: a validated prognostic tool for children. Hepatology. 2020 May 28. doi: 10.1002/hep.31393. PMID:?32464706

Chen J, Ferreira J, Martinez M, Lobritto S, Goldner D., Vittorio J. Role of Budesonide for the treatment of Rejection in Pediatric Liver Transplantation. J Pediatr Gastroenterol Nutr. 2020 May 12. doi: 10.1097/MPG.0000000000002784. [Epub ahead of print] PMID:32404767

El-Matary W, Guthery S, Amir AZ, DiGuglielmo M, Draijer LG, Furuja KN, Gupta N, Hochberg JT, Horslen S, Kerkar N, Koot BGP, Laborda JT, Loomes. KM, Mack C, Martinez M, Miethke A, Miloh T, Mogul D, Mohammmed S, Moroz Stacy Ovchinsky N, Periro ER, Ricciuto A, Sathya, Schwarz K, Shah U, Singh R, Soufi N, Valentino PL, Zizzo A, Denau MR. Colorectal Dysplasia and Cancer in Pediatric-onset Ulcretaive Colitis Associated with Primary Sclerosing Cholangitis. Clin Gastroenterol Hepatol. 2020 Apr 29. pii: S1542-3565(20)30600-5. doi: 10.1016/j.cgh.2020.04.055. PMID: 32360820

Fishman DS, Barth B, Mazziotti MV, Lazar, Brandt ML, Fallon SC, Tsai CM, Orlando SB, Olutoye O, Giefer M, Martinez M, Troendle DM. Same anesthesia session- ERCP and laparoscopic cholecystectomy in pediatric patients: The Pediatric ERCP Database Initiative (PEDI) Experience. J Pediatr Gastroenterol Nutr. 2020 Apr 16. doi: 10.1097/MPG.0000000000002722. [Epub ahead of print] PMID:32304542